abstract：:In the present work, we investigated the effect of non-steroidal anti-inflammatory drugs (NSAIDs) on the monophenolase and diphenolase activity of mushroom tyrosinase. The results showed that diflunisal and indomethacin inhibited both monophenolase and diphenolase activity. For monophenolase activity, the lag time was...

journal_title：International journal of molecular sciences

authors： Sato K,Toriyama M

更新日期：2011-01-01 00:00:00

abstract：:Genetic analysis of plants relies on high yields of pure DNA. For the strawberry tree (Arbutus unedo) this represents a great challenge since leaves can accumulate large amounts of polysaccharides, polyphenols and secondary metabolites, which co-purify with DNA. For this specie, standard protocols do not produce effic...

journal_title：International journal of molecular sciences

authors： Sá O,Pereira JA,Baptista P

更新日期：2011-01-01 00:00:00

abstract：:Nonylphenol (NP) is a degradation product of nonylphenol polyethoxylates, which are widely used in the production of industrial and consumer surfactants. The aim of the present study was to evaluate the effect of NP on the antioxidant capacity and cognitive ability of mice. NP was given orally by gavages at doses of 0...

journal_title：International journal of molecular sciences

authors： Mao Z,Zheng YL,Zhang YQ

更新日期：2010-12-30 00:00:00

abstract：:In this study we used a laser ablation technique for preparation of silver nanoparticles. The fabrication process was carried out by ablation of a silver plate immersed in palm oil. A pulsed Nd:YAG laser at a wavelength of 1064 nm was used for ablation of the plate at different times. The palm coconut oil allowed form...

journal_title：International journal of molecular sciences

authors： Zamiri R,Zakaria A,Ahangar HA,Sadrolhosseini AR,Mahdi MA

更新日期：2010-11-22 00:00:00

abstract：:The glycoprotein P-selectin belongs to the selectin family of cell adhesion molecules. In this study, we cloned the full-length cDNA of P-selectin from zebrafish (Danio rerio) by the method of rapid amplification of cDNA ends polymerase chain reaction (RACE-PCR). Zebrafish P-selectin cDNA is 2,800 bp and encodes a put...

journal_title：International journal of molecular sciences

authors： Sun G,Pan J,Liu K,Wang X,Wang S

更新日期：2010-11-17 00:00:00

abstract：:Previously, we have found that mildronate [3-(2,2,2-trimethylhydrazinium) propionate dihydrate], a small molecule with charged nitrogen and oxygen atoms, protects mitochondrial metabolism that is altered by inhibitors of complex I and has neuroprotective effects in an azidothymidine-neurotoxicity mouse model. In the p...

journal_title：International journal of molecular sciences

authors： Klusa VZ,Isajevs S,Svirina D,Pupure J,Beitnere U,Rumaks J,Svirskis S,Jansone B,Dzirkale Z,Muceniece R,Kalvinsh I,Vinters HV

更新日期：2010-11-09 00:00:00

abstract：:The relationships among 55 wheat accessions (47 accessions collected from Iran and eight accessions provided by the Institute of Plant Biology of the University of Zurich, Switzerland) belonging to eight species carrying A genome (Triticum monococcum L., T. boeoticum Boiss., T. urartu Tumanian ex Gandilyan, T. durum D...

journal_title：International journal of molecular sciences

authors： Ehtemam MH,Rahiminejad MR,Saeidi H,Tabatabaei BE,Krattinger SG,Keller B

更新日期：2010-11-02 00:00:00

abstract：:Aflatoxin B(1) (AFB(1)) is commonly found in cereals and animal feeds and causes a significant threat to the food industry and animal production. Several microbial isolates with high AFB(1) transformation ability have been identified in our previous studies. The aim of this research was to characterize one of those is...

journal_title：International journal of molecular sciences

authors： Guan S,Zhao L,Ma Q,Zhou T,Wang N,Hu X,Ji C

更新日期：2010-10-20 00:00:00

abstract：:Japanese scallop (Mizuhopecten yessoensis) is a cold-tolerant bivalve that was introduced to China for aquaculture in 1982. In this study, amplified fragment length polymorphism (AFLP) markers were used to investigate levels of genetic diversity within M. yessoensis cultured stocks and compare them with wild populatio...

journal_title：International journal of molecular sciences

authors： Liu WD,Li HJ,Bao XB,Gao XG,Li YF,He CB,Liu ZJ

更新日期：2010-10-15 00:00:00

abstract：:We investigated TLR10 expression in human monocytes, THP-1 cells, cultured in hypoxia (3% O(2)). Levels of both TLR10 mRNA and protein in THP-1 cells cultured in hypoxia were significantly higher than those cultured in normoxia (20% O(2)). We examined intracellular reactive oxygen species (ROS) content in hypoxic cell...

journal_title：International journal of molecular sciences

authors： Kim D,Kim YJ,Koh HS,Jang TY,Park HE,Kim JY

更新日期：2010-09-29 00:00:00

abstract：:Here is presented an investigation of the use of normal modes in protein-protein docking, both in theory and in practice. Upper limits of the ability of normal modes to capture the unbound to bound conformational change are calculated on a large test set, with particular focus on the binding interface, the subset of r...

journal_title：International journal of molecular sciences

authors： Moal IH,Bates PA

更新日期：2010-09-28 00:00:00

abstract：:Chitosan, a naturally occurring polysaccharide with abundant resources, has been extensively exploited for various biomedical applications, typically as wound dressings owing to its unique biocompatibility, good biodegradability and excellent antibacterial properties. In this work, composite nanofibrous membranes of c...

journal_title：International journal of molecular sciences

authors： Cai ZX,Mo XM,Zhang KH,Fan LP,Yin AL,He CL,Wang HS

更新日期：2010-09-21 00:00:00

abstract：:The p38α mitogen-activated protein kinase (MAPK) has become an attractive target for the treatment of many diseases such as rheumatoid arthritis, inflammatory bowel disease and Crohn's disease. In this paper, 3D-QSAR and molecular docking studies were performed on 59 p38α MAPK inhibitors. Comparative molecular field a...

journal_title：International journal of molecular sciences

authors： Lan P,Huang ZJ,Sun JR,Chen WM

更新日期：2010-09-17 00:00:00

abstract：:The present work provides a comprehensive overview of the recent progress of research work toward developing new one dimensional (1-D) ceria (CeO(2)) nanomaterials. The review has been classified into three parts: the preparation procedures with identification of the existing different dimensional ceria nanomaterials,...

journal_title：International journal of molecular sciences

authors： Lin KS,Chowdhury S

更新日期：2010-09-13 00:00:00

abstract：:The aim of this article is to review current knowledge related to the synthesis and characterization of sol gel-derived SBA-16 mesoporous silicas, as well as a review of the state of the art in this issue, to take stock of knowledge about current and future applications. The ease of the method of preparation, the orde...

journal_title：International journal of molecular sciences

authors： Rivera-Muñoz EM,Huirache-Acuña R

更新日期：2010-08-31 00:00:00

abstract：:Over the last few decades, vascular endothelial growth factor (VEGF) and pigment epithelium-derived factor (PEDF) have emerged as multifaceted players in not only the pathogenesis, but potential treatment, of numerous diseases. They activate diverse intracellular signaling cascades known to have extensive crosstalk, a...

journal_title：International journal of molecular sciences

authors： Falk T,Gonzalez RT,Sherman SJ

更新日期：2010-08-05 00:00:00

abstract：:Evaluation of relationships between molecular modeling structural parameters and high-performance liquid chromatography (HPLC) retention data of 11 cardiovascular system drugs by principal component analysis (PCA) in relation to their pharmacological activity was performed. The six retention data parameters were deter...

journal_title：International journal of molecular sciences

authors： Stasiak J,Koba M,Bober L,Baczek T

更新日期：2010-07-09 00:00:00

abstract：:Many biological cellular processes occur at the micro- or millisecond time scale. With traditional all-atom molecular modeling techniques it is difficult to investigate the dynamics of long time scales or large systems, such as protein aggregation or activation. Coarse graining (CG) can be used to reduce the number of...

journal_title：International journal of molecular sciences

authors： Spijker P,van Hoof B,Debertrand M,Markvoort AJ,Vaidehi N,Hilbers PA

更新日期：2010-06-09 00:00:00

abstract：:Silk sericin (SS) can accelerate cell proliferation and attachment; however, SS can be extracted by various methods, which result in SS exhibiting different physical and biological properties. We found that SS produced from various extraction methods has different molecular weights, zeta potential, particle size and a...

journal_title：International journal of molecular sciences

authors： Aramwit P,Kanokpanont S,Nakpheng T,Srichana T

更新日期：2010-05-20 00:00:00

abstract：:Stem cells, a special subset of cells derived from embryo or adult tissues, are known to present the characteristics of self-renewal, multiple lineages of differentiation, high plastic capability, and long-term maintenance. Recent reports have further suggested that neural stem cells (NSCs) derived from the adult hipp...

journal_title：International journal of molecular sciences

authors： Hung CW,Liou YJ,Lu SW,Tseng LM,Kao CL,Chen SJ,Chiou SH,Chang CJ

更新日期：2010-05-05 00:00:00

abstract：:Hubs are proteins with a large number of interactions in a protein-protein interaction network. They are the principal agents in the interaction network and affect its function and stability. Their specific recognition of many different protein partners is of great interest from the structural viewpoint. Over the last...

journal_title：International journal of molecular sciences

authors： Patil A,Kinoshita K,Nakamura H

更新日期：2010-04-26 00:00:00

abstract：:In this review we discuss the development of paramagnetic liposomes incorporating MRI contrast agents and show how these are utilized in cellular imaging in vitro. Bi-functional, bi-modal imaging paramagnetic liposome systems are also described. Next we discuss the upgrading of paramagnetic liposomes into bi-modal ima...

journal_title：International journal of molecular sciences

authors： Kamaly N,Miller AD

更新日期：2010-04-15 00:00:00

abstract：:The objective of this study was to evaluate the effect of titanium immobilized with a cationic antimicrobial peptide (JH8194) derived from histatin on the biofilm formation of Porphyromonas gingivalis and differentiation of osteoblastic cells (MC3T3-E1). The titanium specimens (Ti) were immobilized with JH8194, accord...

journal_title：International journal of molecular sciences

authors： Makihira S,Shuto T,Nikawa H,Okamoto K,Mine Y,Takamoto Y,Ohara M,Tsuji K

更新日期：2010-04-02 00:00:00

abstract：:A new aromaticity definition is advanced as the compactness formulation through the ratio between atoms-in-molecule and orbital molecular facets of the same chemical reactivity property around the pre- and post-bonding stabilization limit, respectively. Geometrical reactivity index of polarizability was assumed as pro...

journal_title：International journal of molecular sciences

authors： Putz MV

更新日期：2010-03-26 00:00:00

abstract：:Advances in stem cell research have provided important understanding of the cell biology and offered great promise for developing new strategies for tissue regeneration. The beneficial effects of stem cell therapy depend also by the development of new approachs for the track of stem cells in living subjects over time ...

journal_title：International journal of molecular sciences

authors： Villa C,Erratico S,Razini P,Fiori F,Rustichelli F,Torrente Y,Belicchi M

更新日期：2010-03-12 00:00:00

abstract：:A bacterial strain EMS with the capability of degrading microcystins (MCs) was isolated from Lake Taihu, China. The bacterium was tentatively identified as a Stenotrophomonas sp. The bacterium could completely consume MC-LR and MC-RR within 24 hours at a concentration of 0.7 microg/mL and 1.7 microg/mL, respectively. ...

journal_title：International journal of molecular sciences

authors： Chen J,Hu LB,Zhou W,Yan SH,Yang JD,Xue YF,Shi ZQ

更新日期：2010-03-02 00:00:00

abstract：:Separation of polyphenolic phytochemical compounds from their mixtures with sugars is necessary to produce an added-value sugar-reduced extract with high biological activity from fruit juice processing industry waste streams. The separation characteristics of a binary mixture of rutin and glucose using a Pellicon-2 re...

journal_title：International journal of molecular sciences

authors： Wei S,Hossain MM,Saleh ZS

更新日期：2010-02-09 00:00:00

abstract：:Species delimitation has long been a difficult and controversial process, and different operational criteria often lead to different results. In particular, investigators using phenotypic vs. molecular data to delineate species may recognize different boundaries, especially if morphologically or ecologically different...

journal_title：International journal of molecular sciences

authors： Raduski AR,Rieseberg LH,Strasburg JL

更新日期：2010-02-02 00:00:00

abstract：:Bone adaptation or integration of an implant is characterized by a series of biological reactions that start with bone turnover at the interface (a process of localized necrosis), followed by rapid repair. The wound healing response is guided by a complex activation of macrophages leading to tissue turnover and new os...

journal_title：International journal of molecular sciences

authors： Stanford CM

更新日期：2010-01-25 00:00:00

abstract：:Aqueous solutions of ethoxylated alcohols which form lyotropic liquid crystals at high concentrations (40-80%) were selected as model lubricating substances. Microscopic studies under polarized light and viscosity measurements were carried out in order to confirm the presence of liquid crystalline structures in the ca...

journal_title：International journal of molecular sciences

authors： Sulek MW,Bak A

更新日期：2010-01-12 00:00:00

abstract：:The prognosis of patients with pancreatic cancer remains poor; only patients with small tumors and complete resection have a chance of a complete cure. Pancreatic cancer responds poorly to conventional therapies, including chemotherapy and irradiation. Snail is a transcription factor that has been associated with anti...

journal_title：International journal of molecular sciences

authors： Zhang K,Jiao X,Liu X,Zhang B,Wang J,Wang Q,Tao Y,Zhang D

更新日期：2010-01-01 00:00:00

abstract：:Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) is a powerful tool that enables the simultaneous detection and identification of biomolecules in analytes. MALDI-imaging mass spectrometry (MALDI-IMS) is a two-dimensional MALDI-mass spectrometric technique used to visualize the spatial distribut...

journal_title：International journal of molecular sciences

authors： Zaima N,Hayasaka T,Goto-Inoue N,Setou M

更新日期：2010-01-01 00:00:00

abstract：:Protein microarrays are powerful tools that are widely used in systems biology research. For infectious diseases, proteome microarrays assembled from proteins of pathogens will play an increasingly important role in discovery of diagnostic markers, vaccines, and therapeutics. Distinct formats of protein microarrays ha...

journal_title：International journal of molecular sciences

authors： Natesan M,Ulrich RG

更新日期：2010-01-01 00:00:00

abstract：:Naturally occurring cucurbitacins have been shown to have anticancer, antimicrobial and anti-inflammatory activities. In this study, we determined the effects of cucurbitacin B extracted from the Thai herb Trichosanthes cucumerina L. on telomerase regulation in three human breast cancer cell lines (T47D, SKBR-3, and M...

journal_title：International journal of molecular sciences

authors： Duangmano S,Dakeng S,Jiratchariyakul W,Suksamrarn A,Smith DR,Patmasiriwat P

更新日期：2010-01-01 00:00:00

abstract：:Different concentrations of asafoetida extract were added to the medium of Pleurotus ferulic and the effects of the extract on growth of P. ferulic mycelium and fruiting bodies was observed. As the amount of asafoetida extract additive was increased, the growth of Pleurotus mycelium was faster, the time formation of b...

journal_title：International journal of molecular sciences

authors： Feng Z,Bai Y,Lu F,Huang W,Li X,Hu X

更新日期：2009-12-29 00:00:00

abstract：:Genealogical concordance is a critical overlay of all phylogenetic analyses, irrespective of taxonomic level. To assess such patterns of congruence we have compiled and derived sequence data for two mitochondrial (16S rRNA, COI) and two nuclear (ITS1, p26) markers in 14 American populations of the hypersaline branchio...

journal_title：International journal of molecular sciences

authors： Maniatsi S,Kappas I,Baxevanis AD,Farmaki T,Abatzopoulos TJ

更新日期：2009-12-18 00:00:00

abstract：:This review covers recent advances and work on the microstructure features, mechanical properties and cracking processes of conducting polymer film/coating- substrate structures under different testing conditions. An attempt is made to characterize and quantify the relationships between mechanical properties and micro...

journal_title：International journal of molecular sciences

authors： Wang XS,Tang HP,Li XD,Hua X

更新日期：2009-12-08 00:00:00

abstract：:The structure and function of an enzyme can be altered by nanoparticles (NPs). The interaction between enzyme and NPs is governed by the key properties of NPs, such as structure, size, surface chemistry, charge and surface shape. Recent representative studies on the NP-enzyme interactions and the regulation of enzyme ...

journal_title：International journal of molecular sciences

authors： Wu Z,Zhang B,Yan B

更新日期：2009-11-20 00:00:00

abstract：:High-density polyethylene (PE) foils were modified by an Ar(+) plasma discharge and subsequent grafting with biomolecules, namely glycine (Gly), polyethylene glycol (PEG), bovine serum albumin (BSA), colloidal carbon particles (C) or BSA and C (BSA + C). As revealed by atomic force microscopy (AFM), goniometry and Rut...

journal_title：International journal of molecular sciences

authors： Parizek M,Kasalkova N,Bacakova L,Slepicka P,Lisa V,Blazkova M,Svorcik V

更新日期：2009-11-20 00:00:00

abstract：:Wt% of aragonite, a CaCO(3) polymorph, increased with higher hydraulic activity ( degrees C) of limestone in precipitated calcium carbonate (PCC) from the lime-soda process (Ca(OH)(2)-NaOH-Na(2)CO(3)). Only calcite, the most stable polymorph, was crystallized at hydraulic activity under 10 degrees C, whereas aragonite...

journal_title：International journal of molecular sciences

authors： Kim JA,Han GC,Lim M,You KS,Ryu M,Ahn JW,Fujita T,Kim H

更新日期：2009-11-11 00:00:00